New discovery in Biology and Medicine is strongly driven by new possibilities to visualize the processes of life. To see new things, the SaraLab lab invents and custom builds new types of optical elements and imaging systems. Specific problems in Biology demand that we push technology to the limit in terms of both spatial and temporal resolution. We focus our work on harnessing the power of diffractive Fourier optics in microscopy. This involves design and hands-on nanofabrication of diffractive optics elements for simultaneous 3D imaging using Multifocus microscopy (Abrahamsson et al. Nat. Methods 2013) and super-resolution microscopy (Abrahamsson et al. BOE 2017).
With Sara Abrahamsson's arrival in the Baskin School of Engineering, UC Santa Cruz is becoming a hotbed of advanced microscopy and microscope development.
The National Science Foundation has awarded UC Santa Cruz $700,000 for the development of a multifocus structured illumination microscope. Electrical and Computer Engineering Assistant Professor Sara Abrahamsson will lead the project
Juliana Hernandez, an electrical engineering Ph.D. student at UC Santa Cruz, is spending her summer working with Sara Abrahamsson on a research project which involves using specially designed diffractive optics components for super-resolution microscopy.
We are developing large volume 3D imaging systems to study the function of entire neural circuits in living animals using fluorescence indicators of neural activity. (See previous work in this field: Abrahamsson et al, 2016).